P Sikiric Selected Research

Ranitidine (Zantac)

12/2021	Novel insight into Robert's cytoprotection: complex therapeutic effect of cytoprotective pentadecapeptide pentadecapeptide BPC 157 in rats with perforated stomach throughout modulation of nitric oxide-system. Comparison with L-arginine, ranitidine and pantoprazole therapy and L-NG-nitro-L-arginine methyl ester worsening.
1/2001	Portal hypertension and liver lesions in chronically alcohol drinking rats prevented and reversed by stable gastric pentadecapeptide BPC 157 (PL-10, PLD-116), and propranolol, but not ranitidine.
1/2001	Chronic cytoprotection: pentadecapeptide BPC 157, ranitidine and propranolol prevent, attenuate and reverse the gastric lesions appearance in chronic alcohol drinking rats.
1/2001	Cysteamine-colon and cysteamine-duodenum lesions in rats. Attenuation by gastric pentadecapeptide BPC 157, cimetidine, ranitidine, atropine, omeprazole, sulphasalazine and methylprednisolone.

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P Sikiric Research Topics

Disease

12	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 04/2017 - 01/2001
6	Ulcer 04/2017 - 06/2003
4	Wounds and Injuries (Trauma) 10/2011 - 05/2005
3	Fistula 04/2017 - 01/2012
3	Esophagitis 04/2017 - 12/2006
2	Skin Ulcer 04/2017 - 08/2015
2	Brain Diseases (Brain Disorder) 04/2017 - 04/2010
2	Inflammation (Inflammations) 12/2009 - 01/2001
2	Burns 06/2003 - 12/2001
2	Portal Hypertension 01/2001 - 01/2001
1	Hemorrhage 12/2021
1	Duodenal Ulcer (Curling's Ulcer) 08/2015
1	Brain Injuries (Brain Injury) 10/2013
1	Cerebellar Ataxia (Dysmetria) 10/2013
1	Multiple Sclerosis 10/2013
1	Colitis 10/2013
1	Short Bowel Syndrome 01/2012
1	Ulcerative Colitis 01/2012
1	Pancreatitis 10/2011
1	Hepatic Encephalopathy 04/2010
1	Hyperammonemia 04/2010
1	Hypoglycemia (Reactive Hypoglycemia) 12/2009
1	Bone Resorption 12/2009
1	Fatty Liver 12/2009
1	Hepatomegaly 12/2009
1	Stomach Ulcer (Gastric Ulcer) 12/2009
1	Thrombosis (Thrombus) 12/2009
1	Seizures (Absence Seizure) 12/2009
1	Pain (Aches) 12/2009
1	Periodontal Diseases (Periodontal Disease) 12/2009
1	Periodontitis 12/2009
1	Edema (Dropsy) 12/2001
1	Necrosis 12/2001
1	Shock 03/2001
1	Lung Injury 01/2001

Drug/Important Bio-Agent (IBA)

19	BPC 157IBA 12/2021 - 01/2001
5	Peptides (Polypeptides)IBA 08/2015 - 12/2009
4	Ranitidine (Zantac)FDA LinkGeneric 12/2021 - 01/2001
4	Drinking WaterIBA 08/2015 - 01/2001
2	NG-Nitroarginine Methyl Ester (L-NAME)IBA 12/2021 - 08/2015
2	Arginine (L-Arginine)FDA Link 12/2021 - 08/2015
2	Nitric Oxide (Nitrogen Monoxide)FDA Link 12/2021 - 08/2015
2	Cysteamine (Mercaptamine)FDA Link 10/2013 - 01/2001
2	1-dodecylpyridoxal (PLD)IBA 12/2006 - 11/2003
2	Adrenal Cortex Hormones (Corticosteroids)IBA 05/2005 - 06/2003
1	Pantoprazole (Protonix)FDA LinkGeneric 12/2021
1	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA 04/2017
1	Nitric Oxide Synthase (NO Synthase)IBA 08/2015
1	arginine methyl esterIBA 08/2015
1	CuprizoneIBA 10/2013
1	EnzymesIBA 04/2010
1	Acetaminophen (Paracetamol)FDA LinkGeneric 04/2010
1	Hypoglycemic Agents (Hypoglycemics)IBA 12/2009
1	Insulin (Novolin)FDA Link 12/2009
1	Dopamine AntagonistsIBA 12/2009
1	Liver GlycogenIBA 12/2009
1	Morphine (MS Contin)FDA LinkGeneric 12/2009
1	GlycogenIBA 12/2009
1	Naloxone (Narcan)FDA LinkGeneric 12/2009
1	Haloperidol (Haldol)FDA LinkGeneric 12/2009
1	Evans Blue (Blue, Evans)FDA Link 12/2009
1	Amylases FDA Link 12/2009
1	Blood Glucose (Blood Sugar)IBA 12/2009
1	Silk FDA Link 12/2009
1	Protease Inhibitors (Protease Inhibitor)IBA 05/2005
1	Methylprednisolone Acetate (Depo-Medrol)FDA LinkGeneric 06/2003
1	Methylprednisolone FDA LinkGeneric 06/2003
1	Reticulin (Reticular Fiber)IBA 12/2001
1	CollagenIBA 12/2001
1	Silver Sulfadiazine (SSD)FDA LinkGeneric 12/2001
1	Diazepam (Valium)FDA LinkGeneric 03/2001
1	Anti-Anxiety Agents (Anxiolytics)IBA 03/2001
1	Irritants (Vesicants)IBA 01/2001
1	Cimetidine (Biomet)FDA LinkGeneric 01/2001
1	Atropine FDA LinkGeneric 01/2001
1	SolutionsIBA 01/2001
1	Ethanol (Ethyl Alcohol)IBA 01/2001
1	Propranolol (Inderal)FDA LinkGeneric 01/2001
1	Omeprazole (Prilosec)FDA LinkGeneric 01/2001

Therapy/Procedure

7	Therapeutics 08/2015 - 01/2001
2	Ligation 10/2011 - 12/2009
1	Analgesia 12/2009
1	Lasers (Laser) 05/2005
1	Anesthesia 12/2001
1	Enema (Enemas) 01/2001